Recently, the 863 project “Research and Development of New Controllable Degradable Bone Magnesium Alloy Materials” jointly undertaken by China Special Magnesium Alloy Technology Corporation and the Magnesium Alloy Materials Research Institute of China University passed the technical acceptance. Through the breakthrough of key technologies, this topic has enabled China's high-performance magnesium alloy materials for fully degraded bone repair with independent intellectual property rights to achieve "uniform and controllable degradation" in vivo, and realized large-scale high-quality stable preparation and production. Medical device companies have realized the supply of medical magnesium alloy materials.
Medical magnesium alloy materials and bone implantation devices are known as "revolutionary metal biomaterials" because of their good biocompatibility, toughness and degradability in vivo, and are widely used in fracture internal fixation of bone nails and bone plates , Bone tissue engineering scaffolds and other intraosseous plant materials can promote bone formation, and at the same time, they can degrade and disappear after bone healing, but whether magnesium alloy materials can achieve uniform and controlled degradation is the key to their wide clinical application.
Controllable biodegradable magnesium alloy bone nail and bone plate system
In vivo degradation process of controlled biodegradable magnesium alloy bone screws
The subject has broken through the design of high-strength and controllable degradable magnesium alloy materials, industrial-scale homogeneous clean casting, high-performance magnesium alloy profile extrusion processing, magnesium alloy fracture internal fixation bone nails, bone plate design and precision machining, high adhesion The core technology of strong degradable calcium-phosphorus coating has overcome the problem of uniform degradation of magnesium alloy body, solved the clinical practical problem of gas production in plants in magnesium alloy bone, and obtained controllable degradable magnesium alloy material with completely independent intellectual property rights And mass production technology of fracture internal fixation bone nail and bone plate and mass production. At present, bone nails have completed pre-clinical animal experiments and are being submitted for clinical trials.
Controlled degradation of magnesium alloy materials for bone repair and implanted devices are the key directions of China's future medical device industry development, and have greater clinical needs. The research results have laid a solid material foundation for the development of controlled degradable magnesium alloy bone plant equipment with independent intellectual property rights in China.