Graphene has made new progress in the field of pharmaceutical applications, and news broke out to attract the attention of all walks of life. A few days ago, the Institute of Process Engineering and Tsinghua University confirmed that graphene oxide can form a sandwich superstructure with cell membranes, and achieve effective drug transport in the membrane phospholipid layer. A new precise drug delivery model was discovered, which is new for biomedicine. The design of dosage forms and the application of new nanoparticles provide research directions.
Process engineering researchers conducted a series of experiments and found that two-dimensional particles have distinct biological special reactions from traditional particles, such as the activation of mechanical signals on the cell membrane surface to achieve immunity, and the formation of folding deformation in restricted areas of the cell to induce cell autophagy. Under the premise of rational design, it can effectively improve the effect of vaccine immune response, and realize anti-tumor intelligent treatment and real-time diagnosis. The release of this study made people realize that the interaction between nanometer particles and cells has an important impact on future biomedicine.
Although the graphene-biofilm structure has been predicted, it has not been confirmed. The process engineering R & D team observed the following using cryo transmission technology:
1. Two-dimensional material graphene oxide-biofilm sandwich and its formation process, reveal the effect of sandwich superstructure on cell roughness, cell fluidity, and cell membrane hardness;
2. Two-dimensional graphene oxide can use the sandwich superstructure to allow more drugs to enter the cell, and achieve rapid movement and diffusion of drugs in the membrane phospholipid bilayer, compared with the intracellular delivery effect of liposomes on membrane-specific drugs Increased lethality to cancer cells.
The research on the sandwich structure, inter-membrane diffusion kinetics, and drug delivery process was carried out by a comprehensive and detailed computational simulation and mechanism analysis by researchers at the cooperative unit of the Process Engineering Research Institute.
The discovery of the graphene-biofilm structure has positive significance for the application of graphene in the field of biomedicine, and also promotes the progress of future medicine. Technology changes life, it is no longer an empty word, but it is slowly becoming a reality. I believe that more and more science and technology will be applied to life in the future and change people's lifestyle.